Considerations To Know About indazole ring formation
Substitution at R3 having a halogen or alkoxy group (74f–74i) led to a slight increase in mobile potency with the halide analogs (74g–h) demonstrating optimum the potency from the group. Even further optimization resulted in the discovery of 74i–j, with 74k as essentially the most active compound during the sequence (pIC50 = six.77) with grea